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In other systems, canonical Wnt signaling synergizes with TGF signaling to enhance fibrotic responses (262, 263), and this pathway is first activated in LECs at 12 hours PLI and is found in most if not all fibrotic capsule associated cells (CACs) at 5 and 9 days PLI (261)

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These new studies show small relative NAION risk with GLP-1s mostly in T2D patients (RR ~1.7-2.5), but absolute risks are very low (~0.02-0.08% over years) and attenuated after diabetes adjustment, suggesting confounding more than causation

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Back Raufman, J-P, Tensen, RT, Sutliff, VE, et al (May 1982) 'Actions of Gila monster venom dispersed from guinea pig pancreas', American Journal of Physiology , 242/5, G470-4