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10.1016/j.clinthera.2015.04.002 Clin

Similar to our previous RNA-seq analysis, we demonstrate that treatment with GLP-1MK-801 significantly regulates around 150 times the number of hypothalamic transcripts relative to the weight-matched semaglutide-treated group, emphasizing a mode of action for GLP-1MK-801 that involves biological pathways independent of the GLP-1 receptor signalling pathway (Fig