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46 Nearly complete inhibition of adipocyte differentiation is shown by Oil Red O staining, a 40% reduction in triglyceride accumulation, a 50% decrease of adipocyte marker expression, and upregulation of preadipocyte factor-1 (Pref-1)
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After 3 months, take a 2-month break before repeating
Alternative receptor tyrosine kinases activation The receptor tyrosine kinase family composes of many collaborative members such as EGFR, ErbB2/3/4, MET, Axl, PDGF receptor (PDGFR), and IGF-IR, which share some effectors including PI3K/Akt/mTOR, Ras/Raf/Mek/Erk, Src, and JAK/STAT