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Seek urgent medical attention (contact 999, NHS 111, or attend A&E) if you experience: Black, tarry stools (melaena) may indicate upper gastrointestinal bleeding Bright red blood in or on stools, particularly if accompanied by dizziness, weakness, or rapid heartbeat Pale or clay-coloured stools with yellowing of skin or eyes (jaundice) potential biliary obstruction or liver dysfunction Severe abdominal pain with stool changes, especially if persistent or worsening Stop your GLP-1 medication and seek urgent medical assessment if you develop symptoms suggestive of pancreatitis (severe, persistent abdominal pain which may radiate to your back, with or without vomiting)
In 2022, SAR441255 (GLP-1/GIP/glucagon receptor triagonist) was administered to obese, diabetic primates and healthy lean to overweight humans without diabetes
Large meals: Eating large portions may overstretch the stomach, initiating a reflex that causes diarrhea shortly after eating
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Zamani A, Saki F, Hatami N, Koohpeyma F
In research environments, Tirzepatide has been investigated for its interaction with incretin hormone systems , making it a valuable compound for examining glucose metabolism, receptor activation, and multi-pathway hormonal signaling
