Conclusions Ultimately, the current maintenance dose of 1,000 mcg B12 every 3 months may confer long term harm, therefore it seems that once B12 levels are stabilised well within acceptable range, then the standard B12 intervention of 1000 mcg should be administered annually, and monitored with pre-injection annual testing of levels
This step is crucial for maintaining sterility throughout the process
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1.5 g according to the UK National Health Service (NHS) and British Nutrition Foundation (BNF) Increased requirement: 5 g factors which increase an individuals B12 requirement are illness, stress, toxic stress, pregnancy and breastfeeding Dietary Supply or Supplement Requirement