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Candida auris , fluconazole resistance is associated with an adaptive trade-off: fluconazole-susceptible isolates display enhanced resistance to oxidative stress, whereas the majority (94.5%) of fluconazole-resistant strains exhibit reduced oxidative tolerance ( Several compounds that target fungal antioxidant defenses have shown synergistic effects with existing antifungals

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References Institute for Clinical and Economic Review (ICER)

Athauda D, Budnik N, Chowdhury K, Skene S, Foltynie T