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In the STEP 1 trial (Wilding et al., New England Journal of Medicine, 2021
Growth hormone receptor upregulation amplifies the cellular repair response
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Proposed mechanisms include modulation of GABAergic and glutamatergic signaling, influence on the release of certain hypothalamic and pituitary hormones, and interaction with opioid and serotonergic pathways
This was evidenced biochemically, micro- and macroscopically
Some medical causes of deficiency need ongoing treatment, so tell the team about any existing plan from your GP
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