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Lancet 366 , 12791289 (2005)
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What this means for dosing calculations: the clinical trial protocols use fixed escalation schedules with specific dose targets (typically 8mg or 12mg maintenance)
In controlled lighting studies involving rodents subjected to constant illumination (a stressor that disrupts circadian patterns), intermittent Epithalon treatment normalized melatonin and cortisol rhythms, partially preserving typical daynight physiological cycles [2][4][5]
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