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Higher uptake of BV2-metformin-loaded PLGA was observed in BV2 cells compared to SH-SY5Y, indicating preferential targeting to microglia

These modifications enhance the peptide's stability and resistance to enzymatic degradation, particularly by the enzyme DPP-IV (dipeptidyl peptidase IV), thereby slightly extending its half-life compared to Sermorelin (the unmodified GHRH 1-29)

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