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The symptoms of profound biotinidase deficiency include delayed development, seizures, hypotonia, respiratory difficulties, hearing and vision loss, ataxia, skin rashes, and alopecia
The UACR detects early kidney damage (microalbuminuria) that might not yet affect serum creatinine or eGFR
GLP-1s mimic a hormone important to regulating hunger and metabolism
The mechanisms of kidney protection appear to go beyond glucose lowering
In some studies, people taking tirzepatide lost more weight on average than those taking semaglutide
But many people need structured progression, accountability, and expert adjustment to succeed
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