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If interventions are not started, the increased demand for insulin can overload pancreatic -cells leading to pancreatic -cell failure, decreased insulin secretion, and uncontrolled glycemia (Figure 1)

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Pharmacogn Mag 11(41):74 Frk W, Wojtasiska A, Lisiska W, Mynarska E, Franczyk B, Rysz J (2022) Pathophysiology of cardiovascular diseases: new insights into molecular mechanisms of atherosclerosis, arterial hypertension, and coronary artery disease

Heller RS, Aponte GW (1995) Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(736) amide

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