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After 30 days on the 1.5 mg dose, increase the dose to 4 mg once daily

Its well established that muscle health is a key predictor of longevity, and muscle preservation should be a strategy we all focus on as we try to optimize our health

It activates GLP-1, GIP, and glucagon receptors simultaneously, which means it suppresses appetite, improves insulin response, and increases the rate at which your body burns stored fat

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So I was really excited and really fortunate to spend most of my time talking about GLP-1s

However, the number of heavy drinking days (defined as 4 or more drinks for women and 5 or more for men) decreased significantly more among individuals taking semaglutide compared to the control group (see second figure below): Klausen et al., "Once-Weekly Semaglutide Versus Placebo in Patients With Alcohol Use Disorder and Comorbid Obesity," The Lancet , May 2026