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Side Effect Profile Gastrointestinal (GI) side effects, including nausea, vomiting, diarrhea, and constipation, are the most frequently reported issues with GLP-1 medications and are one of the top reasons people discontinue treatment
The risk of recurrence with rechallenge is not well characterized, but most clinicians would avoid restarting tirzepatide after a confirmed episode of rhabdomyolysis
Commonly reported side effects include: Nausea and vomiting Diarrhea or constipation Decreased appetite In some cases, more serious health concerns have been reported, including: Gastroparesis (Stomach Paralysis) A condition where the stomach empties food very slowly or stops functioning properly, potentially causing severe nausea, vomiting, bloating, abdominal pain, and difficulty eating
One area gaining attention is the use of GLP-1 (glucagon-like peptide-1) receptor agonists
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Research shows these peptides normalize melatonin release, boosting nighttime levels and shifting its peak to 3:00 AM, as seen in younger individuals
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