Notably, TNBC exhibits molecular and metabolic characteristics that enhance its susceptibility to ferroptosis
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Extracellular mtDNA can act as a damage-associated molecular pattern (DAMP), triggering the activation of innate immune receptors such as toll-like receptors (TLRs) and inducing the production of type I interferons (IFNs) [131]
Identifying subjects earlier in the disease course might provide the opportunity for testing the efficacy of an earlier UA intervention when the majority of dopaminergic neurons remain intact