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Several clinical trials have also shown that GLP-1s can reduce an inflammation marker in the bloodbut its still unclear how much of that improvement is the result of weight loss or an independent effect of the drugs

Changhan David Lee and Pinchas Cohen at the USC Leonard Davis School of Gerontology published the first description of MOTS-c in 2015

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Both act as agonists at the GHS-R1a receptor, the same receptor targeted by the endogenous hormone ghrelin

[16] [17] Additionally, persistent nausea, which occurs in up to 44% of patients taking Wegovy at the 2.4 mg maintenance dose, can create a generally unpleasant oral sensation that patients may describe as a bad taste