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10.1016/j.lfs.2023.121814 83
96 Sabatini, S
"These skin, hair and nail changes can happen with any significant weight loss, whether it's through medications, surgery or other means," says Dr
For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results
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