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There is evidence that higher oxidative burden correlates with more circadian rhythm disruption in older organisms, creating a vicious cycle

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Fatigue and weakness: Semaglutide works by suppressing your appetite, which may lead to fatigue (tiredness) and weakness in the initial weeks until your body adjusts to the lower calorie intake

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Larger subcutaneous injection volumes (above 0.5mL) can cause more local discomfort, swelling, and slower absorption