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264,265 Chronic hyperglycemia elevates ROS production through multiple pathways, including enhanced glucose oxidation, activation of NADPH oxidases, and dysfunction of the mitochondrial electron transport chain
This is the design intent: better cellular potency per microgram
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Moreover, it was also reported that long-term injection of geniposide and exenatide did not induce nociceptive tolerance (98, 99)
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