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In clinical trials, semaglutide has consistently outperformed other marketed anti-obesity and weight loss drugs in terms of both effectiveness and safety
These findings add to a growing body of anecdotal and pharmacovigilance data suggesting that clinicians and patients should be aware of these unusual neurological reactions
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Methods Data from patients in the PIONEER 35, 7 and 8 trials receiving once-daily oral semaglutide (14 mg/flexibly dosed) or a comparator (placebo, sitagliptin 100 mg or liraglutide 1.8 mg) were analysed for efficacy (glycated haemoglobin [HbA 1c ] and body weight changes from baseline to planned end of treatment) and safety outcomes
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That said, achieving a healthier weight before pregnancy improves virtually every pregnancy outcome measure
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