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[9] The study hypothesized that Sermorelin may influence the pathway involving growth hormone and IGF-1, with IGF-1 levels correlated with growth hormone and thought to mediate hGH's anabolic actions

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RETA induced immune reprogramming systemically and in the tumor microenvironment with durable anti-tumor immunity evidenced by elevated circulating IL-6, increased antigen presenting cells, reduced immunosuppressive cells, and activation of pro-inflammatory pathways

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Although EMPEROR-R enrolled patients with and without type 2 diabetes, the primary outcome of the trial (a composite of CV death and hospitalization for HF) was almost identical in both groups, suggesting that the different population didnt affect the results, at least for the primary outcome