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In clinical studies, participants experienced significant reductions in fasting glucose levels, with an average decrease of 8.35 mg/dL compared to a negligible change in the placebo group

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These cytokines not only promote synoviocyte activation, induce chondrocytes and osteocytes to produce MMPs, and cause joint tissue damage, but also activate T and B cells, further exacerbating inflammation (Berg et al., 2010

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