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Indeed, preclinical studies have shown that GLP-1 RAs inhibit key inflammatory pathways in experimental models, reducing the production of proinflammatory cytokines (e.g., TNF-, IL-1, IL-17, IL-23) and even modulating the activity of innate immune cells

DPP-4 is also known to be cleaved from cell membranes in a cell specific manner that results in soluble circulating DPP-4

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These medications mimic the natural GLP-1 hormone that helps regulate appetite, blood sugar levels, and digestion

In a large clinical trial sponsored by Novo Nordisk, the manufacturer of Ozempic and Wegovy, participants were randomly assigned to either receive semaglutide or the matching placebo

All can be used by adults, but some are also approved for children