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PGC-1 as a Pivotal Factor in Lipid and Metabolic Regulation
BMC Health Serv Res 21(1):582
Oxidative stress in the pathogenesis of diabetic neuropathy
As cited above, the amino acid cysteine is a rate-limiting factor for GSH synthesis, and a variety of both clinical trials and in-vitro/in-vivo data suggest that supplying cysteine as NAC is an effective strategy for enhancing GSH production and intracellular cysteine.Intravenous NAC has been utilized for some time to treat acetaminophen and non-acetaminophen induced acute liver failure by restoring the concentration of GSH, and has been found to be safe and effective
[1] These effects are typically dose-dependent, most pronounced during dose escalation, and tend to diminish over time
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