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And though they are less common, headaches and constipation are also potential side effects

Over time, this energy shortfall sets off a cascade of downstream effects: synaptic dysfunction, impaired protein clearance, neuroinflammation, and ultimately the accumulation of amyloid- and tau pathology Importantly, imaging and metabolic studies consistently show that reductions in cerebral glucose metabolism and perfusion precede cognitive symptoms by years, often decades [8]

To manage demand in the NHS, there will be a phased introduction for delivering GLP-1 medications to eligible groups, based on clinical need

Nihon Rinsho 2007;65(6):1005-1010

However, experts say the process is becoming quicker especially if there is a high level of interest and competition

Diabetes 52 (1), 102110