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Gastroenterology 2011;141:150-6.ArticlePubMed 52

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Most clients stay on microdosing for 612 months, tapering once appetite regulation and lifestyle patterns feel sustainable

doi: 10.1210/clinem/dgab722 58 ForzanoIVarzidehFAvvisatoRJankauskasSSMonePSantulliG

In a 10-week clinical trial, a daily dose of 20 mg oral semaglutide achieved a steady-state plasma concentration of 30 nM, and when daily dose of oral semaglutide was increased to 40 mg, the semaglutide plasma concentration reached about 60 nM (102), which was over a thousand times higher than the EC50 of semaglutide for GLP-1R activation (95)

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