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It is responsible for inactivating incretins, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)

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These modifications extend the half-life from minutes to days, making once-weekly dosing possible

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L- 4-6 , 2 ,

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4 = never), where always represents a frequency of 10 out of 10 times, very often: 89 out of 10 times, sometimes: 47 out of 10 times, rarely: 13 out of 10 times, and never: 0 out of 10 times

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