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Target 1.21.6 g/kg (about 0.50.7 g/lb) body weight daily
As a general principle, most DPP-4 inhibitors require dose reduction or avoidance in moderate-to-severe renal impairment
In the latter, excessive extracellular matrix deposition leads to structural and functional impairment, culminating glomerular sclerosis (83)
Ghezzi et al., 2019
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