Results: Both peptides increased proinflammatory cytokine secretion by unstimulated RAW 264.7 macrophages and these effects were blocked by the NF-B cascade inhibitor, stress-activated protein kinase (SAPK)/JNK cascade inhibitor and, to a lesser extent, Toll-like 4 receptor activity inhibitor
But the FDA flagged a serious adverse event, including a death, associated with an IV ipamorelin infusion (although it wasnt clear whether the peptide directly caused the participant's death)
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