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Their activity is strongly implicated in barrier breakdown following trauma, stroke, and neuroinflammation, positioning MMPs as key mediators of CNS injury and attractive therapeutic targets [101, 258]
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However, in a single case report of a 7.8 kg terrier mixed breed dog with compulsive disorder, five months of treatment with 5 mg melatonin twice daily along with a combination of cannabinoids and behavioral therapy reduced compulsive behavior and led to easier management by the owner
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