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In contrast to CM, MM harbors a low single nucleotide mutation burden, but a high number of chromosomal structural variants ( BRAF and NRAS mutations, which are widely present in CM, are less frequent in MM ( SF3B1 and KIT , loss of CDKN2A, PTEN , or SPRED1 , as well as amplification of CDK4, TERT, KIT, MDM2 , or CCND1 , are more common in MM ( Table 2 compares the genetic profile between CM and MM

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