However, people with obesity who are insulin resistant or diabetic who lose weight generally improve glucose, insulin and lipid metabolism [9]
However, the biggest problem in the therapeutic use of GLP-1 is its extremely short half-life in plasma (~2 min)
Glucagon-like peptide-1 (GLP-1) receptor agonists represent a class of medications originally developed for type 2 diabetes management, with some now FDA-approved for chronic weight management
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Over time, researchers and clinicians recognized their significant impact on body weight, leading to FDA-approved indications for chronic weight management