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Under physiological conditions, the Neh2 structural domain of Nrf2 binds to Kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm, facilitating Nrf2 ubiquitination and subsequent degradation (32)

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Milk thistle, scientifically named silybum marianum, is originally native to Southern Europe through to Asia but today found throughout the world

Strong chelators, phosphate-rich buffers and reducing agents in an experimental medium will compete for the copper centre and change the species actually present

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