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The standardized mean difference (SMD) and 95% confidence interval (CI) used to compare the effect size ( 2 + SD final 2 ) (2 0.5 SD baseline SD final)] ( 2 estimation ( 2 values less than 25% as low heterogeneity, values between 25 and 50% as moderate heterogeneity, and values exceeding 50% as high heterogeneity

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