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The GIP receptor-GLP-1 receptor dual agonist, tirzepatide, ranks among the most effective therapeutic agents within treatment of obesity and diabetes to date ( The only GIP receptor antagonist administered in humans for a longer period, is the aforementioned AMG133, which is an antagonistic GIP receptor antibody conjugated to two agonistic GLP-1 receptor peptide analogues ( Besides the complex pharmacological interplay between the GIP receptor targeting ligands and the receptor addressed above, another aspect of GIP biology is the tissue-specific actions, which might affect the clinical results of GIP targeting treatments
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