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Inhibiting the enzyme pharmacologically aims to reproduce that effect, which is why multiple independent NNMT inhibitors have been developed
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This approach has philosophical appeal for those seeking to optimize underlying biology rather than override it
Semaglutide Semaglutides mechanism of action is very different but still impactful
Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available
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