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The inhibitory effect of GLP-1 on glucagon secretion in vivo was observed only when the blood glucose level was equal to or higher than the fasting level, at higher blood glucose levels, the inhibition of glucagon gradually increased (Holst, 2007), and when the blood glucose concentration was less than 3.7 m mol/L, GLP-1 lost its effect on inhibiting glucagon secretion (Nauck et al., 2002)

Using medication beyond the expiration date means the manufacturer can no longer guarantee its potency, purity, or safety

Thyroid function testing (TSH, free T4) should be current before attributing treatment failure solely to the injection

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