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Across the cagrilintide clinical program, the dominant tolerability issues have been gastrointestinal: nausea, reduced appetite, constipation, and, less commonly, vomiting a profile shared with pramlintide and with GLP-1 agonists, and mechanistically expected from a compound that slows the stomach and engages the area postrema
G., Haftek, M., Creidi, P., Lapire, C., Nusgens, B., Richard, A., Schmitt, D., Rougier, A., & Zahouani, H
Boyd A, Thomas R, Hansell AL, Gulliver J, Hicks LM, Griggs R, et al
Patients with sulphonamide allergy can safely use these products
Subsequent replication in Japan, involving 200,000 subjects, confirmed the same finding
M.Macedo-de la ConchaL
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