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This is why weight loss is often one of the first treatment recommendations for women with PCOS who are overweight or obese

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This means the "master antioxidant" never makes it to your cells in its complete, functional form

A meta-analysis of 24 weight-loss intervention studies (N=2,284) found that a 10 kg reduction in body weight raised total testosterone by approximately 2.9 nmol/L and SHBG by 5.7 nmol/L in men with obesity [3]

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You would need complications like severe heart failure, respiratory failure, or organ damage directly attributable to obesity