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It is not a drug, dietary supplement, food additive, cosmetic, or therapeutic agent, and must not be used in or on humans or animals

A higher concentration of plasma 5HT, which was stored in platelets, may reflect an elevated activity of the 5HT transporter, and, as a result, greater sensitivity to SSRIs in those patients

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The reduction in CAT and SOD synthesis or their activity, or excessive ROS formation, may explain the decrease in their activities, and the decrease in cellular GSH may result from NADPH inhibition by MTX (Alfwuaires 2022)