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In research settings, compounds such as orforglipron are evaluated for their structural and mechanistic properties using controlled laboratory systems
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Caron A, Lee S, Elmquist JK, Gautron L (2018) Leptin and brain-adipose crosstalks
Glia 63, 16361645, doi: 10.1002/glia.22833 (2015)
When fatty acids are transported to the mitochondria more efficiently, more usable energy becomes available
This hormone-based mechanism differs fundamentally from bupropion's neurotransmitter approach
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