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A safe, clinically supervised approach should include: a full medical assessment before treatment begins screening for contraindications and medicines that may interact gradual dose escalation to minimise side effects regular monitoring of weight, blood pressure and relevant blood tests where appropriate nutritional advice to ensure adequate protein, vitamins and hydration support to maintain muscle mass through physical activity and resistance exercise behavioural strategies to develop sustainable eating habits regular follow-up appointments to review progress, manage side effects and determine whether treatment remains appropriate People taking these medicines should also be advised about recognising symptoms that require prompt medical review, such as persistent severe abdominal pain, signs of dehydration or ongoing vomiting

It may feel similar to the early stages of arthritis

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Results vary among individuals