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DCFHDA can react with ROS to generate 2,7-dichlorofluorescein (DCF), which would produce green fluorescence

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After 1 week of induction, all of the mice were sacrificed, and the blood was harvested for plasma UA determination, while the heart was harvested for real-time qPCR, western blotting, lipidomics analysis and immunofluorescence examination

The top drugs inducing hearing loss include antimicrobials (aminoglycosides antibiotics, vancomycin, anti-malaria drugs), platinum and other anti-cancer drugs (cisplatin, methotrexate), loop diuretics, macrolide antibiotics, chemotherapeutic agents, such as acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), and quinine (Mattson et al

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Moreover, all studies that did not specify the inclusion/exclusion criteria for fertile participants were excluded from this review analysis