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In both lower and higher eukaryotes, the initiation of autophagy requires the assembly of specific protein complexes: (1) the Atg1-Atg13-Atg17 (ULK1-Atg13-FIP200 in mammals) kinase complex, which initiates phagosome formation at the phagophore assembly site (PAS, an Atg8-rich cytoplasmatic site) (Kabeya et al., 2005

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This inflammation causes swelling around nerve roots, sensitizes pain receptors, and can perpetuate discomfort even after the initial injury begins to heal

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