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Proposed model for LB nucleation and growth The existing LB models, namely (1) the aggregation/fibrillization theory and (2) the liquidliquid phase separation model, largely theorize monomeric Syn solely as a precursor with fibrillization as the pathological endpoint, ultimately, LB formation

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Acknowledgements We thank L MHamdi and L Puydenus from SBEC-BEC (Support Biopathologique aux Etudes Cliniques - Bureau des Etudes Cliniques) from Institut Claudius Regaud-IUCT-Oncopole for TMAs and technical support