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Sleep disruption increases neuroinflammation, especially in the hippocampus, with chronic sleep disruptions worsening inflammatory responses in the brain ( Bmal1 expression ( 4.2 Direct evidence Regarding direct mechanisms, urolithin A may have potential modulatory effects on central clock genes ( Clock , Bmal1 , Per , Cry ), a pathway partially supported by existing preclinical data
A1 astrocytes show a neurotoxic profile, contributing to synaptic loss, whereas A2 astrocytes exhibit neuroprotective properties
In fact, ganitumab has been approved as orphan drug in Ewing sarcoma by the US Food and Drug Agency
