This review article summarizes the current knowledge on redoxin-driven processes related to ferroptosis, a non-apoptotic cell death mechanism based on uncontrolled oxidation of polyunsaturated fatty acids in membranes
Although studies have shown that FOXO4-DRI can block the binding of P53 to FOXO4, thereby promoting the apoptosis of senescent cells, the effect of FOXO4-DRI is not limited to alleviating the aging of certain organs
Its known for its ability to cross the blood-brain barrier and stimulate BDNF (Brain-Derived Neurotrophic Factor) a molecule essential for memory, learning, and neuronal repair
3- Glutathione Delays Aging: Again, free radicals are one of the main factors of aging, and glutathione, which reduces free radicals that age and damage cells, is thought to slow down aging indirectly
Tsirves GK, Voulgari PV, Pelechas E, Asimakopoulos AD, Drosos AA
Future studies should investigate whether HIF stabilization directly modulates erythrocyte apoptotic pathways, such as by upregulating anti-apoptotic genes or downregulating pro-apoptotic factors