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These acidic cylinders stack via basic linker polypeptides to form rods that connect to the PBS core (Anderson and Toole, 1998)

This naturally occurring substance is found in all mammalian tissues, especially striated muscle, and is required in energy metabolism, such as the oxidation of fatty acids, facilitating the aerobic metabolism of carbohydrates, and enhancing the excretion of certain organic acids

Specifically, macrophages activate TNF-like weak inducer of apoptosis (TWEAK) through the CCL5/TRAF6/NF-B pathway, leading to muscle atrophy

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Figure 2c: From step 1 (left) to steps 2 and 3 (right)

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