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Glucocorticoid metabolism is largely controlled by 11-HSD1 and GR and has been shown to be strongly linked to Body Mass Index, as intra-adipose cortisol levels are increased relative to inactive cortisone in the obese state, even if circulating cortisol levels remain stable

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However, its ability to reduce visceral fat and improve metabolic health has broadened its appeal to others seeking these benefits

Others note that because research shows that collagen supplementation may help people with joint pain become more mobile and thus exercise more it could be a useful component of a weight loss plan