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A meta-analysis found indeed a significant reduction of systolic and diastolic blood pressures with SGLT2 inhibitors ( Whether SGTL2 inhibitors increase the risk of amputation of lower limbs (toes, feet, or legs) was highly debated in the literature with clinical trials showing controversial results ( Finally, in terms of safety, a recent case report showed myotoxicity secondary to the concomitant administration of rosuvastatin and canagliflozin (Figure 1 and characteristics of aforementioned safety clinical studies are shown in Table 2