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For most healthy individuals the uncertain TMAO signal does not translate into a proven harm, but it is a reason to be cautious, to monitor health markers, and to favor products and doses aligned with human trial practice

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Because exogenous -KG can be converted to succinate through dioxygenases 27 , we wondered whether shGDH1 cell death is rescued by -KG or -KG-derived succinate

Based on the available data, experts recommend initiating studies at MK-677 doses no higher than 25mg/daily